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The active functional core of glutathione is the thiol (sulfhydryl, -SH) group located on the cysteine residue, which acts as the primary electron donor

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Tumor microenvironment-activated ultrasensitive nanoprobes for specific detection of intratumoral glutathione by ratiometric photoacoustic imaging

Specially, excessive ROS promotes cellular senescence by upregulating cyclin-dependent kinase inhibitors such as p16, leading to irreversible cell cycle arrest

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