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Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]
Gastrointestinal side effects of the non-peptide GLP-1 receptor agonists: A systematic review and meta-analysis
Evidence suggests that GLP-1RAs do not directly prevent gout attacks, but are effective in managing cardiometabolic conditions commonly associated with gout and other arthritides
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Some studies also suggest functional selectivity, meaning these compounds activate certain signaling pathways more than others, which may explain differences in side-effect profiles
Common side effects include gastrointestinal symptoms (nausea, diarrhoea) with GLP-1 agonists and oily stools with orlistat
