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A previous study indicated that capsiate enhances GPX4 expression and suppresses ferroptosis through the activation of transient receptor potential cation channel subfamily V member 1, along with the attenuation of intestinal I/R injury [88]
Its therapeutic action is believed to arise mainly from melanocortin receptor signaling in the brain, including pathways involving the hypothalamus, medial preoptic area, limbic system, and dopamine-associated sexual-motivation networks
doi: 10.1371/journal.pone.0138537 106 TakahashiSSaegusaJOnishiAMorinobuAet al