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Jung-Im Shin, an epidemiologist at the Johns Hopkins Bloomberg School of Public Health

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The mechanisms of GLP-1 to improve NAFLD include improving lipid metabolism by regulating metabolism-related signaling pathways such as AMPK pathway [33] and JNK pathway [105]

In contrast, GLP-1RAs provide prolonged systemic effects, making them well-suited for managing chronic conditions like T2D and obesity

However, native GLP-1 has a limited half-life (1.55 min) due to its degradation by the enzyme Dipeptidyl peptidase 4 (DPP-4), necessitating the development of GLP-1 receptor agonists (GLP-1RAs) with longer activity (Campbell and Drucker 2013)