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Theres a lot of controversy amongst pediatricians, pediatric endocrinologists and physicians in general about how we should be treating pediatric obesity, says Oshman

Tirzepatide affects glucose and appetite signaling pathways in the brain and pancreas, triggering reduced food intake and potential nausea in some patients

Surg 16 (2008) 8897, 10.5435/00124635-200802000-00006

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When a biosimilar is approved based on a clinical program in one indication, the FDA may approve it for all indications held by the reference biologic without separate clinical trials in each, provided the mechanism of action is the same and there is no scientific reason to expect differential clinical behavior across the populations