The tight budget argument, when used, is often a blanket statement referring to the overall pressure on NHS resources, not the specific cost of a single appointment
Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production
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Do not use the vial
Energetics and substrate use Indirect calorimetry at thermoneutrality quantifies energy expenditure, RER, fatty-acid and carbohydrate oxidation rates, and activity
The two are not interchangeable: bacteriostatic water has no electrolytes
