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A study published in Frontiers in Nutrition found that L

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Semaglutide slows gastric emptying as part of its glucose-lowering action, which can lead to gastrointestinal symptoms such as nausea and reduced appetite

Semaglutide [2] is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the GLP-1 hormone naturally produced in the gut

It is the first medication to meaningfully address both sides of the energy balance equation: | Medication | What It Reduces | What It Burns | Max Weight Loss | |-----------|----------------|---------------|-----------------| | Semaglutide | Appetite (GLP-1) | -- | ~15-17% | | Tirzepatide | Appetite (GIP + GLP-1) | Minimal | ~20-22% | | **Retatrutide** | **Appetite (GIP + GLP-1)** | **Calories (Glucagon)** | **~24%** | That additional glucagon column is why retatrutide achieved more weight loss in less time than either competitor

They may also feel dry or appear cracked due to the bloods lack of oxygen and nutrients