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Despite the acknowledged limitations, these two metanalyses reach a consistent conclusion: the combination of SGLT2i and GLP-1RA is associated with significantly lower all-cause mortality and superior cardiorenal outcomes compared to monotherapy in patients with T2DM
These pathways do not directly target central sensitization, neuroinflammation, or pain processing mechanisms implicated in fibromyalgia
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A short-term administration of LG results in an unchanged or slightly elevated BP while the long-term administration has the opposite effect
More research is needed to verify whether this anticipatory effect is present so that future studies can take this into account when planning sampling intervals
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