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GSH directly neutralizes ROS (reactive oxygen species), regenerates oxidized vitamins C and E, and serves as a co-substrate for glutathione peroxidase (GPx) and glutathione S-transferase (GST)

The role of retinal pigment epithelium in the Involution of subretinal neovascularization

GSH is widely found in animals and plants, especially in yeast

In apoptosis, -sitosterol upregulates pro-apoptotic factors such as p53 and Bax, while downregulating anti-apoptotic proteins such as Bcl-2, leading to an increase in mitochondrial outer membrane permeability and the activation of key apoptotic enzyme cascades such as caspase-9 and 3, which induces programmed cell death (83)

Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M

Protease K, a serine protease with broad cleavage activity, was employed to evaluate the protease stability of D-CuP in vitro