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Where patients were previously instructed to not stop their GLP-1 medication and to fast from midnight the night before surgery, she said patients taking GLP-1 agonists are now instructed to consume clear liquids for 24 hours prior to surgery

If you need to adjust your dosing day, shift by no more than 48 hours

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A vial that looks perfectly clear and normal may have lost 20-30% of its active peptide through deamidation and hydrolysis without any visual indication

It has been hypothesised, based largely on data from tirzepatide studies, that GIPR agonism may moderate some of the gastrointestinal side effects associated with GLP-1R stimulation