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Bound and unbound pyridine dinucleotides in normal and glucosa-6-phosphate dehydrogenase-deficient erythrocytes

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Additionally, ROS promote arrhythmias by disrupting potassium channel function, inducing endoplasmic reticulum and mitochondrial dysfunction, and causing electrical conduction disturbances between endothelial cells and cardiomyocytes [329]

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In particular, two phase 4 clinical trials (NCT02422927 and NCT03470376) tested the ability of a nutraceutical combination containing 500 mg BBR to ameliorate inflammation lipid profile and endothelial injury markers in patients with elevated levels of high-sensitivity C-reactive protein and in HIV-infected patients receiving stable antiretroviral therapy