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With obesity affecting roughly 40 percent of American adults and oral formulations now reaching the market, GLP-1s are on track to become even bigger

There are concerns about acute pancreatitis, thus its recommended to discontinue liraglutide upon symptom onset and avoid use in individuals with a history of pancreatitis

In addition, it also enhances the pancreatic and duodenal homeobox gene-1 (PDX-1) transcription mediator expression, which further regulates the bio-synthesis of insulin, glucose transporter 2 , and differentiation of beta cells